Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability
نویسندگان
چکیده
منابع مشابه
genomic and epigenetic instability in colorectal cancer
abstract: colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women worldwide. both genetic and epigenetic alterations are common in crc and are the driving force of tumorigenesis. chromosomal instability, microsatellite instability and cpg island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. chromosom...
متن کاملMicrosatellite instability in colorectal cancer
BACKGROUND Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequence of inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis colorectal cancer (HNPCC) represen...
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Background: Activator protein 2 alpha (AP-2a) is involved in a variety of physiological processes. Increased AP-2a expression correlates with progression in various squamous cell carcinomas, and a recent publication found AP-2a to be overexpressed in ,70% of Head and Neck Squamous Cell Carcinoma (HNSCC) patient samples. It was found to repress transcription of the tumor suppressor gene C/CAAT E...
متن کاملAP-2α Induces Epigenetic Silencing of Tumor Suppressive Genes and Microsatellite Instability in Head and Neck Squamous Cell Carcinoma
BACKGROUND Activator protein 2 alpha (AP-2alpha) is involved in a variety of physiological processes. Increased AP-2alpha expression correlates with progression in various squamous cell carcinomas, and a recent publication found AP-2alpha to be overexpressed in approximately 70% of Head and Neck Squamous Cell Carcinoma (HNSCC) patient samples. It was found to repress transcription of the tumor ...
متن کامل[Microsatellite instability among patients with colorectal cancer].
BACKGROUND In patients with colorectal carcinoma, insertions or deletions of short sequences of DNA, a phenomenon called microsatellite instability, are observed. AIM To look for microsatellite instability and mutations of MLH1 and MSH2 gene mutations in patients with colorectal carcinoma. MATERIAL AND METHODS Ten patients with sporadic colorectal carcinoma and 31 patients fulfilling criter...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2005
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1209009